Microbial Genomics

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چکیده

It is well known that the gut microbiota regulates homeostasis of the digestive system; however, the mechanisms involved have been difficult to uncover. By manipulating the germ environment of Drosophila alongside genomic analyses of its symbiont, Acetobacter pomorum, Shin et al. (2011) deduce a pathway that relies on the collaboration between a bacterial enzymatic reaction and the host insulin signaling pathway. Drosophila play host to five main species of bacteria; completely wiping out the microbiota in germ-free larvae is lethal in a specific-diet condition, with these larvae only reaching 10% of the size of wild-type before they expire. The authors show that recolonization by A. pomorum alone is sufficient to restore development and growth rate. To identify mutants that no longer restored growth in recolonized germ-free larvae, Shin et al. constructed a draft genome of A. pomorum and screened a newly generated mutant library. This effort uncovered a number

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عنوان ژورنال:
  • Cell

دوره 147  شماره 

صفحات  -

تاریخ انتشار 2011